学 术 报 告 一

报告题目：纳米技术及其在药剂学中的应用：以TPGS/Poloxamer复合槲皮素负载纳米胶束为案例研究

报 告 人：Professor Ts. Dr. Liew Kai Bin  University  of  Cyberjaya

时    间: 2025年10月20日（星期一）10:20

地    点：鄞州校区2阶二

参加人员：欢迎感兴趣的师生参加

学 术 报 告 二

报告题目：负载岩藻聚糖海洋提取物的海洋质纳米载体的制备，表征及其抗氧化活性增强研究

报 告 人：Phang Hiu Ching  University  of  Cyberjaya

时    间: 2025年10月20日（星期一）11:10

地    点：鄞州校区2阶二

参加人员：欢迎感兴趣的师生参加

主题简介

纳米技术及其在药剂学中的应用：以TPGS/Poloxamer复合槲皮素负载纳米胶束为案例研究

Nanotechnology has revolutionized pharmaceutical sciences by enabling precise, efficient, and patient-friendly drug delivery. This presentation explores the application of nanotechnology in pharmaceutics, focusing on the optimization of a luteolin-loaded nanomicelle system composed of TPGS and Poloxamer 407. Luteolin, a bioactive flavonoid with anti-cancer and multidrug-resistance reversal potential, suffers from poor solubility and low bioavailability. To overcome these limitations, a micellar system was developed using the thin-film hydration method followed by freeze-drying. Optimization studies identified a 3:1 TPGS-to-Poloxamer ratio and 10% surfactant concentration as ideal, achieving high encapsulation efficiency (~90.7%) and favorable particle size with enhanced stability. Characterization through DLS, FTIR, and XRD confirmed micelle integrity, while in-vitro assays demonstrated improved solubility and controlled release profiles. This nanomicelle system significantly enhanced luteolin’s dissolution and therapeutic potential, suggesting promising translational value in cancer therapy. The presentation also highlights other patient-friendly dosage innovations—such as orally disintegrating films (ODFs), chocolate-based fast-melt tablets, and probiotic melt films (ProbiMelt)—illustrating how nanotechnology and formulation science synergize to improve drug delivery, bioavailability, and patient compliance. Collectively, these innovations underscore nanotechnology’s pivotal role in shaping the next generation of pharmaceutics and personalized medicine.personalizedmedicine.

负载岩藻聚糖海洋提取物的海洋质纳米载体的制备，表征及其抗氧化活性增强研究

Introduction: The increasing demand for natural antioxidants has intensified interest in marine bioactives. Fucoidan, a sulfated polysaccharide from brown seaweed, has potent antioxidant properties but faces challenges in bioavailability and stability. This study developed a novel marine lipid-based nanocarrier (marinosome) to encapsulate fucoidan, enhancing its delivery for topical applications. Objective: To develop and characterized marinosome encapsulated fucoidan marine extract with enhanced anti-oxidant properties. Methodology: The krills lipid, cetyl alcohol and soy lecithin were added in a beaker with 30 mL of chloroform and heated to 50 °C. Then, fucoidan extract was added to 50mL of distilled water and heated at 50 °C. Later, the nanoparticles polymer solution was added to the fucoidan extract solution dropwise and stirred constantly for homogeneity. The chloroform in the mixture solution was removed through rotavap and dry under the fumehood overnight. Mixture solution was washed with distilled water and freeze dried for 48 hours. Results: The encapsulation efficiency (EE) was measured and among the 5 formulations, M05 achieved the highest EE at 93.538 ± 0.099 % (p < 0.05), had a stable zeta potential at -19.160 ± 4.655 mV, size of marinosome was consistent and uniform (Particle size = 174.288 ± 15.642 nm, PDI = 23.7 ± 3.7 %). Result supported by DSC and FTIR spectroscopy showed successfully encapsulation. The anti-oxidant of the nanoparticles was also 27.04 ± 8.97 % higher than pure powder indicates a good scavenging activity. IC50 of fucoidan extract was 622.357 mcg/mL and after loaded into marinosome it achieved IC50 of 349.560 mcg/mL indicates a strong anti-oxidant activity. Conclusion: The study successfully developed and characterized a novel marinosome formulation for encapsulating fucoidan marine extract. The optimized formulation (M05) demonstrated excellent encapsulation efficiency, stability, and uniform particle size. The enhanced antioxidant activity of the encapsulated fucoidan, as evidenced by a lower IC50 value and a higher scavenging percentage compared to the pure extract, confirms that the nanocarrier system effectively improved the therapeutic potential of fucoidan. This research supports the use of marinosomes as a promising delivery system for enhancing the efficacy of bioactive marine compounds in topical applications.